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PDX Stem Cell

Connections among proteins, cells and tissues

Reading list

Cardiac cells, actin and follicle experiments

The collection begins with a cardiac protein complex, then follows actin, follicle cells and the tissue that has to function afterwards.

The cardiac connection

The mouse cardiac study opens the register with a protein complex, cell migration and survival. Philp and colleagues’ hair-follicle study adds a stem-cell connection in rats, mice and rat follicle cells.

The molecular and chemical subjects

The actin-bound structure examines a constructed hybrid complex. The equine analytical paper identifies the TB-500 fragment and detects it and its metabolites. The multifunctional thymosin review supplies broader context for the full protein’s activities. These papers have distinct experimental tasks.

Function and safety

The cardiac study in mice gives migration company in survival and function. The mdx mouse study makes the arrival question harder. The healthy-volunteer Phase 1 study and musculoskeletal narrative review are useful companions when the discussion approaches human use.

References cited

  1. Thymosin beta4 increases hair growth by activation of hair follicle stem cells ↗
  2. Structural basis of actin sequestration by thymosin-beta4: implications for WH2 proteins ↗
  3. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair ↗
  4. Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications ↗
  5. Evaluation of skeletal and cardiac muscle function after chronic administration of thymosin beta-4 in the dystrophin deficient mouse ↗
  6. A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin β4 in healthy volunteers ↗
  7. Doping control analysis of TB-500, a synthetic version of an active region of thymosin β4, in equine urine and plasma by liquid chromatography-mass spectrometry ↗
  8. Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance ↗