# Cardiac cells, actin and follicle experiments

> Connections in print | PDX Stem Cell — The PDX Stem Cell reading list gathers follicle stem-cell migration, actin structure, cardiac and muscle experiments, fragment identity and human safety.

**Reading list**

The collection begins with a cardiac protein complex, then follows actin, follicle cells and the tissue that has to function afterwards.

## The cardiac connection

The [mouse cardiac study](https://pubmed.ncbi.nlm.nih.gov/15565145/) opens the register with a protein complex, cell migration and survival. [Philp and colleagues’ hair-follicle study](https://pubmed.ncbi.nlm.nih.gov/14657002/) adds a stem-cell connection in rats, mice and rat follicle cells.

## The molecular and chemical subjects

The [actin-bound structure](https://pubmed.ncbi.nlm.nih.gov/15329672/) examines a constructed hybrid complex. The [equine analytical paper](https://pubmed.ncbi.nlm.nih.gov/23084823/) identifies the TB-500 fragment and detects it and its metabolites. The [multifunctional thymosin review](https://pubmed.ncbi.nlm.nih.gov/22074294/) supplies broader context for the full protein’s activities. These papers have distinct experimental tasks.

## Function and safety

The [cardiac study in mice](https://pubmed.ncbi.nlm.nih.gov/15565145/) gives migration company in survival and function. The [mdx mouse study](https://pubmed.ncbi.nlm.nih.gov/20126456/) makes the arrival question harder. The [healthy-volunteer Phase 1 study](https://pubmed.ncbi.nlm.nih.gov/20536472/) and [musculoskeletal narrative review](https://pubmed.ncbi.nlm.nih.gov/41966639/) are useful companions when the discussion approaches human use.

## References

[1] Thymosin beta4 increases hair growth by activation of hair follicle stem cells https://pubmed.ncbi.nlm.nih.gov/14657002/
[2] Structural basis of actin sequestration by thymosin-beta4: implications for WH2 proteins https://pubmed.ncbi.nlm.nih.gov/15329672/
[3] Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair https://pubmed.ncbi.nlm.nih.gov/15565145/
[4] Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications https://pubmed.ncbi.nlm.nih.gov/22074294/
[5] Evaluation of skeletal and cardiac muscle function after chronic administration of thymosin beta-4 in the dystrophin deficient mouse https://pubmed.ncbi.nlm.nih.gov/20126456/
[6] A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin β4 in healthy volunteers https://pubmed.ncbi.nlm.nih.gov/20536472/
[7] Doping control analysis of TB-500, a synthetic version of an active region of thymosin β4, in equine urine and plasma by liquid chromatography-mass spectrometry https://pubmed.ncbi.nlm.nih.gov/23084823/
[8] Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance https://pubmed.ncbi.nlm.nih.gov/41966639/

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PDX Stem Cell is my register of connections through published research on cells, an editorial undertaking with no clinic or business service and no medical advice.